<This video is meant for academic purpose only.>
►【International Young Scholar Forum】
Title：Structural basis of antagonizing the vitamin K catalytic cycle revealed by termini restraining method
Time: December 16, 2021
Speaker: Dr. Shixuan Liu，Washington University School of Medicine, USA
Abstract:
Vitamin K antagonists (VKAs), such as warfarin, are the commonly used anticoagulants worldwide to treat and prevent thromboembolic diseases. Warfarin targets VKOR, an oxidoreductase highly expressed in liver that support blood coagulation. In this talk, I will show the catalytic cycle and inhibitory mechanism of VKAs. VKOR is a small membrane protein that was refractory to purification, here I will also show the method we introduced to work it through.
References
1. Liu S et al, Science, 2021
2. Liu S et al, Science Advances, 2020
3. Liu S et al, Nature Protocols (Accepted)
Brief CV of Dr. Shixuan Liu:
Dr. Liu received his Ph.D. in Institute of Biophysics, Chinese Academy of Sciences in 2011. Then he moved to Washington University in St Louis for postdoctoral training. Now he is a senior scientist. He mainly focuses on membrane proteins related to blood coagulation, especially VKOR, the target of warfarin. He is also interested in protein engineering as well as other new technologies. Results are published in journals like Science, Science Advances, Nature Communications, Nature protocols, PNAS and so on and so forth.